That precious 16 mg sample has been through more purification trauma than a reality show contestant. Six rounds of isolation after failed reactions is the biochemistry equivalent of running a marathon in lab shoes. Your sample isn't just tired—it's contemplating retirement and writing a memoir titled "Diminishing Returns: My Life as a Microscopic Speck." The most tragic relationship in science isn't with your PI—it's with that compound you've been trying to synthesize for months while watching your starting material slowly vanish into the void of contaminated fractions and stuck-to-glassware losses.
The Last Surviving Milligrams

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