The nerdiest hormone pun ever! Looking at the molecular structures, estrogen has a phenol group with an OH attached directly to a benzene ring, giving it that extra "p+" (proton). Meanwhile, testosterone is structurally similar but lacks this particular phenol arrangement.
It's basically organic chemistry dad humor. The "p+" refers to a proton (H+), which is what makes the difference in that hydroxyl group position. The subtle chemical distinction between these sex hormones creates their vastly different biological effects, yet they're remarkably similar structurally - just a proton's difference in the right place!
Chemistry nerds unite! This is what happens when biochemists try to make jokes at parties.