Physics: universal constants that govern everything from subatomic particles to galactic superclusters. No exceptions. No complaints.
Chemistry: "Well, these two elements should react predictably based on their properties... unless it's a Tuesday... or there's a full moon... or Mercury is in retrograde... or the grad student had coffee that morning."
The visual representation using buff doge vs. crying doge is painfully accurate. Spent three years trying to reproduce a "simple" organic synthesis only to discover the original paper conveniently omitted that it only works at 23.7°C while humming Beethoven's 5th.