Nothing destroys your dreams of academic greatness quite like calculus! The top frame shows someone confidently strutting down a hallway with "ME TRYING TO ACHIEVE ALL MY GOALS" - that beautiful moment of optimism before reality hits. Then BAM! The bottom frame shows someone getting absolutely wrecked by a car with "BASIC CALCULUS" plastered across it.
For those who've ever stared at sec²(x) and wondered why the derivative of tan(x) wants to hurt you personally, this is your emotional support meme. Calculus doesn't just trip you up - it full-on vehicular homicides your GPA while laughing.