This meme is peak organic chemistry wordplay. SN2 reactions involve nucleophilic substitution where one group gets kicked out as another swoops in—basically molecular ghosting. The joke brilliantly compares relationship dynamics to chemical mechanisms: she won't leave her current partner (the leaving group) until a suitable replacement (the nucleophile) comes along. The backside attack approach of SN2 reactions makes this even more deliciously awkward. Chemistry students everywhere just snorted coffee through their noses.
Nucleophilic Substitution Of The Heart

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