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Every organic chemist's nightmare captured in one perfect meme! That moment of pure joy when you isolate your product (top panel) - it's beautiful, it's pure, it's EXACTLY what you wanted... until you decide to recrystallize it "just to be safe" (bottom panel). Suddenly your beautiful yield drops from 85% to a soul-crushing 12%, and your supervisor is asking why you needed three more weeks to finish the synthesis. The universal lab tragedy that's spawned the sacred chemist's prayer: "Please don't disappear in purification."
The title references the ultimate backup plan - when recrystallization fails, you resort to column chromatography, which is basically playing hide-and-seek with your molecule through a tube of silica while crying softly into your lab notebook.
