Nothing triggers existential dread in a chemist like watching your carefully prepared column chromatography go sideways! Those tailing peaks are the lab equivalent of watching your entire research project collapse in real-time. Instead of nice, clean separation of compounds, you get this smeared disaster that makes your chromatogram look like a toddler's fingerpainting. Hours of prep work down the drain because your silica gel decided today was the day to rebel against the laws of chemistry. Every scientist knows that specific scream of despair when you realize you'll need to re-run everything... for the fifth time this week.
The Chromatography Scream

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