This is cellular biology turned into a bizarre Chad meme. The "virgin smooth ER" (endoplasmic reticulum) is portrayed as pathetic—making "stupid lipids" and lacking ribosomes, while the "Chad Rough ER" flexes with ribosomes attached to its membrane surface "like his bitches" and produces functional proteins. It's basically cell organelle trash-talk. The nucleolus reference is just the cherry on top of this cellular hierarchy nonsense. Next time you're looking at a cell diagram, you'll never unsee the rough ER as the bodybuilder of the cytoplasm.
The Cellular Hierarchy: Smooth ER vs. Chad ER

biology-memes, cell-biology-memes, endoplasmic-reticulum-memes, ribosomes-memes, proteins-memes | ScienceHumor.io