The cellular equivalent of "I'm going to destroy this whole man's career." The p53 protein (aka the guardian of the genome) sees DNA damage and immediately calls for apoptosis—programmed cell death—like an overzealous building inspector condemning a house for a single crack in the foundation. "That's a lot of damage? How about a little more?" is basically p53's motto when it decides your cell is too sketchy to continue existing.
It's the ultimate biological tough love—killing individual cells to prevent mutations from spreading and potentially causing cancer. Your body commits cellular genocide roughly 60 billion times daily just to keep you alive. Talk about sacrificing the few to save the many!