The noble gases are having a handshake party, but poor helium got the cold shoulder! The meme cleverly plays on the "-on" suffix shared by all noble gases (neon, argon, krypton, xenon, radon)... except helium, which ruins the pattern. That's why it's in quotation marks and gets ejected from the group. Chemistry humor at its finest - exclusionary yet educational. Noble gases are typically non-reactive, but apparently they're quite reactive when it comes to grammatical consistency!