Molecular modeling Memes

The eternal struggle of biochemists trying to avoid thermodynamics while studying protein folding! Pure chemists smugly embrace entropy and enthalpy, while biochemists are stuck looking at these colorful protein visualization programs wondering how these complex molecules actually fold into functional shapes. The molecular modeling software (CCP4MG) shown here is the biochemist's way of saying "I'll just visualize it and hope nobody asks me about Gibbs free energy calculations." Spoiler alert: protein folding is literally governed by thermodynamic principles that determine which conformations are energetically favorable. You can run from thermodynamics, but those alpha helices and beta sheets will find you!

The eternal nightmare of organic chemistry students everywhere! That "S" drawing is the infamous Schlegel diagram of cyclohexane - the molecular structure that haunts dreams and ruins GPAs. Drawing this perfectly on exams is like trying to perform brain surgery with oven mitts. The reply "Now load it in chem3d an optimize" is the modern chemist's equivalent of "just use a calculator" - completely missing the existential crisis of having to draw these by hand during tests. The perfect representation of that moment when you realize your beautifully drawn chair conformation looks more like abstract art than actual science.