Red blood cells having an existential crisis! These little cellular discs are basically the ultimate minimalists of mammalian evolution—they've ditched their nucleus, mitochondria, and other organelles to maximize hemoglobin-carrying capacity. The meme hilariously portrays them threatening to reject millions of years of evolutionary specialization and revert to their primitive prokaryotic ancestors.
It's the cellular equivalent of threatening to move back in with your parents after college. Except in this case, "parents" are single-celled organisms from billions of years ago. That's one dramatic family reunion!