Thermostable Memes

Regular DNA polymerase is that crying cat giving a thumbs up—trying to act tough but clearly dying inside at 80°C. Meanwhile, Taq polymerase is just chilling in literal hellfire with a coffee mug saying "this is fine." That's because Taq comes from Thermus aquaticus , a bacteria that lives in hot springs and basically laughs at temperatures that would denature other proteins into sad little molecular puddles. This is why PCR works—Taq keeps replicating DNA while the thermal cycler is basically cooking everything else. The molecular equivalent of that friend who somehow thrives in saunas that make everyone else pass out.