Starvation Memes

The existential crisis of a mitochondrion without glucose is truly tragic. "The powerhouse of the cell" suddenly becomes "the unemployed factory worker of the cell." Without its precious glucose fuel, it's sitting there like a Ferrari with an empty tank, desperately wanting to make ATP but having nothing to work with. The cellular equivalent of showing up to work only to find the office building locked and everyone laid off. No glycolysis upstream means no pyruvate delivery, and that's how you get a metabolic drama worthy of cellular Shakespeare.